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Curr Gerontol Geriatr Res 2012:184042

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You can also learn more about vitamin B12, weight loss, and wellness by exploring the ThinWorks blog and client resources. Final Takeaway: The Best Time to Take Vitamin B12 For most people, the best time to take vitamin B12 is in the morning or early afternoon, ideally on an empty stomach with a glass of water, so it can support daytime energy and avoid potential sleep disruption