4-hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage
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Histone deacetylases (HDAC2), a member of the HDAC family, is correlated with insulin signaling components in postsynaptic glutamatergic neurons of the adult mouse hippocampus, and hyperactivity of the HDAC system (including HDAC2) may result in the suppression of the insulin signaling system and consequent disruption of synaptic plasticity in type 2 diabetes
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Furthermore, calcium signal recording of DMH GLP-1R neurons highlighted that learned anticipation of food induces a significant increase in neural activity even before contact with food