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otherwise, the amount of insulin injected is more than necessary, and it will cause several problems adversely affecting and hurting the patients

Sarcopenia is a progressive skeletal muscle disorder characterized by a decline in muscle mass, strength, and gait speed 124,249,250

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In turn, ROS can damage the mitochondrial DNA or electron transport chain components, causing a further increase in ROS production or interact with mitochondrial permeability transition pore to release apoptogenic factors or with the endoplasmic reticulum (ER) to cause Ca 2+ dysregulation and ER stress (Puspita et al., 2017