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Pharmaceutical companies initially developed GLP-1s for diabetes treatment, but they are now widely prescribed for weight loss

That modification is the key engineering trick: it makes the molecule more resistant to the enzymes that would normally break GHRH down quickly, giving tesamorelin a longer working window than sermorelin while still acting on the same GHRH receptor

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Specifically, Asp 21P forms a salt bridge with R242 ECL1 , while Trp 25P forms a hydrogen bond with D244 ECL1 and pi-pi stacking with W249 ECL1 , which was stabilized by Phe 22P