Even though epidemiology may be of some help in orientating the clinician and even though some lesions may confidently be diagnosed on clinical grounds alone, the definitive diagnosis usually requires histopathologic evaluation
Discoloration (greenish or brownish tint) indicates oxidative degradation
Natarelli N, et al
2.1 Study design In this prospective, double-blind, cross-over interventional study, patients were randomized in balanced blocks (1:1) into two groups: Sequence 1, HA-first, received the control product (containing only hyaluronic acid 0.2%) for 4 weeks, followed by a 1-week washout, and then the experimental product (hyaluronic acid 0.2% + butyroyl glutathione 0.4%) for 4 weeks
Immunobiology 221 (3), 486493
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