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The decision to add B12 is made by individual prescribers working with compounding pharmacies, which is why B12 only appears in compounded formulations

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Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, et al

Important Safety Information Contraindications and Precautions: Joint injections should only be performed by qualified medical professionals Active joint infection is an absolute contraindication to intra-articular injection Bleeding disorders or anticoagulation therapy may increase injection risks Pregnancy and breastfeeding: no safety data available, avoid use Cancer history: while AOD-9604 does not affect IGF-1, consult oncologist before use Monitoring Recommendations: Regular follow-up with joint imaging and functional assessments to evaluate treatment response

In addition, it can help relieve symptoms of certain disorders by reducing inflammation in the body and improve joint flexibility

doi: 10.1038/ejcn.2014.165