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The Physiology of Glucagon-like Peptide 1

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16 Nonetheless, other GLP-1 RAs such as albiglutide has also shown reductions on MACE risk up to 22% as demonstrated by the HARMONY trial

The glucagon component increases energy expenditure and fat oxidation, a mechanism unique to retatrutide that semaglutide (GLP-1 only) and tirzepatide (GLP-1/GIP) lack