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These patches usually show up on the forehead, cheeks, nose, and upper lip, but in some cases, they may extend to the neck or forearms

Abstract Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO - ) generation during aging

Csiszr et al., 2014)