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Patients experiencing such symptoms should contact their GP or diabetes specialist nurse promptly

Some are mild, while others can be intense

Brain insulin resistance in Alzheimers disease and related disorders: mechanisms and therapeutic approaches

Key findings for semaglutide duration include continued weight loss through at least 68 weeks with no plateau in many patients, weight regain of approximately 40% of lost weight within seven months of stopping, and withdrawal effects including increased appetite, food cravings, and in some cases gastrointestinal changes

JAMA 2025;333:1062-73.ArticlePubMedPMC 136

This has led to increased interest in GLP-1 drugs for weight management, even among non-diabetics