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I think what the potential efficacy of GLP-1 agonists for substance-use disorders is telling us, is suggesting is that there may be this kind of final common pathway, this core underlying biology of desire, of wanting things that may transcend food or alcohol or other things and may reflect something fundamental about the way the brain processes these feelings
The biochemical mechanism of G6PD deficiency is strongly contingent on the fact that in normal red blood cells, G6PD decreases exponentially as red blood cells age, with a half-life of about 50 days (as discussed earlier in this chapter)
Good digestion isnt just about what you eat, its also about how calm and relaxed you are when you eat
Gutkind, Signals and receptors
Previous melanocortin agonists that failed clinical trials for general obesity share common features that constrain their therapeutic windows, including low receptor potency, poor safety profiles, and suboptimal pharmacokinetics
Sermorelin is closer to the body's natural signal and has more safety data behind it
