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When the medication is stopped, these effects cease and appetite increases again

Therefore, dogs in this ancillary study had been receiving treatment (either placebo or rapamycin) for durations ranging from one to six months based upon their date of enrollment into the clinical trial

Data acquisition and processing were carried out using MassLynx version 4.1 (Waters Corp., Milford, MA, USA)

Hypothalamus, specifically the arcuate nucleus and the dorsal vagal complex in the brain stem, are the most relevant structures involved in this function.1 The role of the arcuate nucleus and the brain stem consists in an integration within signals coming from periphery and recognized in the gut hormones2 (Fig