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English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JP

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In controlled laboratory systems, investigators employ in vitro and animal injury paradigms such as skin wound repair , tendon and ligament damage , muscle degeneration , gastrointestinal inflammation , pulmonary injury , and neuroinflammatory conditions to explore peptideassociated signaling effects (9,10)

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In addition, extracellular lactate stabilizes HIF-2, and HIF-2 then transactivates MYC, increasing the levels of glutamine transporters and GLS1, in turn resulting in increased glutamine catabolism 72