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In the few studies that interrogate cerebral effects, APAP intoxication is associated with spatial and non-spatial memory deficits alongside elevated levels of oxidative stress and gliosis 26,27,28,29,30,31,32
NO can also reversibly nitrosylate cysteine residues and inhibit mitochondrial cytochrome c, leading to increased production of superoxide that locally reacts with NO to form peroxynitrite (the extremely reactive nucleophile ONOO-) (Moncada and Bolaos, 2006
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T., Lin, G., Wu, P
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Insight into the essential role of the helicobacter pylori Hp1043 orphan response regulator: Genome-wide identification and characterization of the DNA-binding sites
