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Increasing growth hormone by significant amounts has been shown in some animal studies to reduce life span by up to 50%, while reducing levels has been shown to boost life span by up to 33%

Delaying administration by six hours shifts the peptide's distribution profile toward liver, adipose, and other non-muscle tissues where IGF receptors remain at baseline expression

doi: 10.1016/j.freeradbiomed.2010.09.006 69 ChangTWangROlsonDJHMousseauDDRossARSWuL

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The WHO recommends lower cutoffs for Asian populations: obesity at BMI 27.5 (versus 30 standard) and overweight at BMI 23 (versus 25 standard)