Bodybuilders and athletes have explored IGF-1 DES for "targeted" muscle development in lagging body parts, though such applications raise ethical and safety questions
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Cell pellets were resuspended in 0.3 ml small-scale lysis buffer (20 mM potassium phosphate, 200 mM NaCl, pH 7.4, 1 mg ml 1 lysozyme, 0.75 mg ml 1 polymyxin B, 0.01 mg ml 1 DNase I) per well and incubated at 30 C, 300 rpm, 5 cm shaking diameter for 30 min
In new data from a phase 2 dose-ranging trial, researchers found weight loss continued to increase up to 13 weeks for adults with overweight or obesity
The label also has a new Risk Evaluation and Mitigation Strategy (REMS) program that aims to mitigate the risk of complications (such as infection, bleeding, pain) due to improper insertion and removal of the device
The regulatory landscape creates both challenges and opportunities