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Analysis of recently determined crystal structure of human GGT also confirms high mobility of the lid loop (West et al., 2013)

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We confirmed, although less efficiently reacting with the Ub-PA probe compared to the SUMO1/3-PA probes, SnCE1 shows weak DUB activity cleaving Lys11-, Lys48- and Lys63-linked di-ubiquitin (diUb) chains, with preference for the latter (Fig

A metabolite basis set was generated using MRSCloud(Hui et al., 2022), which included the following metabolites: ascorbate (Asc), aspartate (Asp), creatine (Cr), GABA, glycerophosphocholine (GPC), GSH, glutamine (Gln), Glu, myo-inositol (mI), lactate (Lac), N-acetyl aspartate (NAA), N-acetyl aspartyl glutamate (NAAG), phosphocholine (PCh), phosphorcreatine (PCr), phosphoryl ethanolamine (PE), scyllo-inositol (sI), and taurine (Tau)