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3 Here we describe an integrated chemical, pharmacological and structural approach to elucidate mechanisms of signal transduction by the glucagon-like peptide-1 receptor (GLP-1R), based on comparisons involving two natural agonists, GLP-1 and exendin-4, and rationally designed analogues of these peptides

However, the current research remains largely limited to animal models and small-scale clinical trials, necessitating further large-scale, multicenter clinical studies to validate their efficacy and safety

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The interactions of some antioxidant enzymes with oxidants, antioxidants, or other bioactive molecules contribute to the management of NCDs, as briefly described below