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The GLP-1 and GIP components help counterbalance this effect, but the titration schedule accounts for it by allowing the body to find equilibrium at each dose level before escalating
Am J Physiol Endocrinol Metab 278: E1010-1018, 2000
In contrast, long acting GLP-1 receptor agonists have relatively little effect on the rate of gastric emptying due to the development of tachyphylaxis resulting from continuous activation of the GLP-1 receptors in the GI tract (Nauck et al, 2011
Adequate protein intake during weight loss reduces but may not eliminate this effect