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In addition, these CQDs disaggregated mature fibrils with low cytotoxicity, indicating their potential for both prophylactic and therapeutic intervention in protein-misfolding disorders [144]

CAR-T-cell therapy, which has revolutionized the treatment of hematologic malignancies, is now being adapted to target CSC-specific antigens in solid tumors

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Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

In addition, GSTA4 expression levels could also predict the risk of IA in women (AUC = .87, p = .005, Figure 4C)