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Its main mechanism of action is based on increasing the expression of BDNF (Brain-Derived Neurotrophic Factor) and its TrkB receptors in the hippocampus and prefrontal cortex, promoting synaptic plasticity, long-term potentiation (LTP), and memory consolidation (Dolotov et al., Neuroscience 2006)

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Matsuoka H, Hayashi T, and Takigami K, et al (2020) Correlation between immune-related adverse events and prognosis in patients with various cancers treated with anti PD-1 antibody BMC Cancer 20 (1) 656 PMID: 32664888 PMCID: 7362440

DPP-4 also cleaves cytokines and chemokines, contributing to inflammation [11]

Kisspeptin Kisspeptin regulates gonadotropin-releasing hormone pulses and therefore controls puberty and fertility cycles