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In the pharmacological interaction with immune receptors (p-I) model, the drug noncovalently inserts in the immunological synapse, altering activation

DOI: 10.1038/s41467-024-50199-y

Generating MTA1 -overexpressed cell lines HEK 293T/17 cells were transfected with pTFORF2895 (Addgene, 144355) to generate MTA1 lentivirus as described above

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36 Through the cGAMPSTINGTBK/IKK axis, it induces NF-B-dependent expression of inflammatory cytokines such as IL-6 and CXCL10, promoting the SASP