Dopaminergic neurons in the enteric nervous system also express high levels of TH and the DAT, but they lack the dopamine -hydroxylase enzyme that converts dopamine into norepinephrine (Li et al., 2004)
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Dopamine supplementation would be evident, but this hydrophilic neurotransmitter does not cross the BBB and cannot enter the CNS due to brain endothelial tight junctions, active brain endothelial metabolism and lack of transporters [5]
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