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When gut inflammation disrupts tryptophan metabolism, shunting it toward the kynurenine pathway instead of serotonin synthesis, the brain experiences a serotonin deficit even when dietary tryptophan intake is adequate

10.1155/2013/409321 135 MonaF

FDA approval ensures that the medications have been thoroughly tested, but ongoing research continues to monitor their long-term effects

Notably, GLP-1 RAs also tend to promote growth of genera known for supporting gut barrier integrity (such as Akkermansia ), further hinting at a positive remodeling of the gut ecosystem (34, 35)