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Resnick O, Bril F, Beauchamp G

For most patients, GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) require long-term use to maintain their benefits

People interested in gut health and peptide research should understand that Akkermansia also produces propionate, a short-chain fatty acid that contributes to metabolic regulation

These typically include nausea, occasional vomiting, diarrhea, constipation, and abdominal discomfort

A First Look at the Numbers A 2026 study published in The Lancet Obstetrics, Gynaecology, and Women's Health took a direct look at this question, evaluating 120 postmenopausal women treated with tirzepatide, one of the most effective GLP-1 and GIP dual receptor agonists currently available [16]