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Studies in animal models and human cells have demonstrated that exposure to particulate plastics can induce oxidative stress and cytotoxic effects as well as disrupt energy homeostasis, metabolism and immune function

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On the other hand, the activation of STAT3 induced the expression of IGF-1R [51] indicating that the cytokine-mediated JAK/STAT3 pathway was able to sensitize insulin/IGF-1 signaling

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