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Ongoing human studies aim to determine whether GLP-1RAs reduce plaque formation directly or they just stabilize the plaque avoiding its rupture [36]

These medications work by adjusting appetite, digestion, and blood sugar regulation, so when that support is removed, those systems can shift back quickly

When people lose weight, they can also lose muscle mass, particularly if they are not getting enough protein or doing resistance exercises

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Within 2 days the obsession with food stopped

Additionally, Cleveland Clinic published real-world data in March 2026 tracking nearly 8,000 patients who discontinued GLP-1 therapy