These DSBs are then initiated and amplified through the coordinated activation of multiple DNA damage response (DDR) pathways, mediated by DDR kinases such as ATM, DNA-PK, and CHK2, along with their downstream effector molecules (e.g., p53 and NF-B) [74, 75]
What's going on, dude
Various anatomic locations of surgically proven endometriosis: a single-center experience
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(29) indicated that the average relative intensity of propionylcarnitine (C3:0), and butyrylcarnitine (C4:0) in plasma of overtired and depressed rats was lower than that of healthy control group
doi:10.1016/j.molmet.2017.04.010 45