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Underlying mechanisms contributing to cardiovascular and renal protection are at least partially different between GLP-1RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (mainly systemic and intrarenal hemodynamic changes)

Trends Mol Med (2001) 7(10):44754.10.1016/S1471-4914(01)02104-9 274 SaccaLCittadiniAFazioS

Clinical studies have shown significant reductions in body weight and improvements in overall metabolic health

Please note that while GLP-1 drugs can be helpful for some, those who are using it for weight loss will need to consider other lifestyle modifications, such as weight-bearing exercise, to make sure theyre not losing too much muscle mass

He says the reports didnt provide much actionable health advice

exclusivity window to justify continued manufacturing investment