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It under-serves the meaningful minority whose response is shaped by GIPR, GLP1R, FTO, MC4R, and TCF7L2 variants genes that influence dual-agonist response (the GIP arm of tirzepatide), GLP-1 receptor sensitivity, appetite regulation, satiety signaling, and insulin response respectively
Mounjaro (tirzepatide) is a GLP-1 and GIP receptor agonist that helps with weight loss by slowing gastric emptying, controlling appetite, and regulating blood sugar
2017, Guida and Ramracheya 2020, Lafferty, Flatt et al
Semaglutide is a GLP-1 receptor agonist that mimics the natural GLP-1 hormone, helping increase insulin production, reduce glucagon levels, slow digestion, and promote feelings of fullness
WADA status DSIP is not currently listed on the World Anti-Doping Agency Prohibited List