An important role is to inactivate incretins (GLP-1 & GIP)
doi: 10.1053/j.gastro.2019.03.049 69 PottsR
Clinical Evidence Behind Semaglutide Effectiveness The STEP trials, a series of landmark clinical studies involving over 4,500 participants, demonstrated semaglutide's substantial impact on weight reduction and cardiometabolic outcomes
Although the FDA has issued a boxed warning for semaglutide, based on animal studies indicating a risk for thyroid C-cell tumors [48], no target-organ toxicity emerged, and there was no signal for thyroid C-cell hyperplasia, an observation later corroborated in clinical trials
Gels 9 (5), 398
In the event of BD, obtained results are more limited than in other psychiatric disorders, although some authors argue that because of the nature of BD and its therapy, the field of epigenetics can be critical for understanding the clinical course of this complex disorder, aiding to define the role of environmental factors, and the possible identification of promising state and traits biomarkers [25]
