If standard approaches do not work, extending the escalation timeline is preferable to microdosing
However, some side effects can arise from GLP-1 agonist use
Pharmacokinetics: approximate terminal half-life 6 days, Cmax at 40-48 hours post-injection, steady-state in 4-5 weeks
That's the heart of the gutGLP-1 axis: fermentable fiber becomes short-chain fatty acids, SCFAs signal through FFAR2 and FFAR3, and your body's own appetite and glucose hormones respond
They also have defined rules for stopping or adjusting study treatment
Less than a week after her second dose, Ms Hancocks had arrived with extreme jaundice, constant nausea, vomiting, severe constipation, stomach swelling, and fatigue so complete she could barely move