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This particular class of drug is going to help immensely for downgrading the burden of cardiovascular disease and nephropathy in people with type 1 diabetes, and maybe prolong their life, Garg said

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Pharmacol Rev 2008

The average duration of diabetes was 6.2 years, and patients were on at least 1,500 mg of metformin with a mean HbA1c of 8%

Once within the mitochondria, PGAM5 dephosphorylates AIFM1 at Ser116, ultimately resulting in the induction of oxeiptosis in HeLa cervical cancer cells [74]

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