doi: 10.1016/j.ejphar.2023.175801 191
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Zhang, K., Zhou, Y., Feng, G
Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro
79,80 GLP-1 has also shown superiority to thiazolidinedione (e.g., rosiglitazone) because GLP-1 therapy does not accompany side effects like peripheral edema, weight gain, congestive heart failure, and osteoporosis, which are common in thiazolidinedione therapy
Tirzepatide has been found to improve markers of -cell function, such as increased HOMA2-B indices and reduced proinsulin levels, proinsulin/C-peptide ratios, and proinsulin/insulin ratios, indicating better insulin processing and reduced -cell stress [22,23]