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Eur J Epidemiol 31:125136 Schmidt M, Pedersen L, Srensen HT (2014) The Danish civil registration system as a tool in epidemiology

By mimicking the hormone released in the stomach after eating, GLP-1s prompt the body to produce more insulin and maintain blood sugar levels

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Semaglutide does not directly deplete NAD, but rapid weight loss and dietary restrictioncommon during early semaglutide therapymay stress cellular energy systems

This is because having a higher body weight, especially weight carried around the middle, can lead to insulin becoming less effective and being produced in smaller quantities