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Retatrutide simultaneously activates GIP, GLP-1 and glucagon receptors, a triple-agonist pharmacological profile that has dominated late-stage metabolic research

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Proton pump inhibitors (PPIs) such as omeprazole or pantoprazole may help patients experiencing concurrent reflux symptoms, as delayed gastric emptying can worsen gastroesophageal reflux disease

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244 Conversely, the expression level of GLP-1R on -cells is relatively high

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