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Validation strategies, split-sample testing, permutation analyses, and receiver operating characteristic (ROC) curves, have confirmed the discriminatory capacity of small metabolite panels (46 compounds), with many models reaching area under the curve (AUC) values greater than 0.85
The rate production of the pink pigment was used as a quantitative measure of enzyme activity
Annu Rev Biochem 45: 559604
in 1980
Biol Chem 384: 505516
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