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4.1
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Description

Each dose increase typically occurs at 4-week intervals , allowing adequate time to assess tolerance

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23 The FDA recommends that patients remain on each dose of certain GLP-1 RA therapies, namely semaglutide, dulaglutide, and tirzepatide, for at least 4 weeks before dose increases

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The rationale is that weight loss beyond 15% often produces clinically meaningful improvements in joint symptoms, and retatrutide consistently crosses that threshold at moderate doses

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