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Int J Mol Sci 2020;21:4003.ArticlePubMedPMC 11

Udupa and Prakash 70 assert that biomarkers generated during tubular injury, such as KIM-1 and NGAL, can be more precise, early, real-time, and proportionate to injury than traditional markers

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is yes, if your dark circles are due to pigmentation or oxidative stress, and if your supplement is well-formulated