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The Journal of clinical endocrinology and metabolism, 110(1), 115

All the patients fulfilled the criteria established by the American Society for Reproductive Medicine and the European Society for Human Reproduction and Embryology for diagnosing the presence of PCOS (20), and at least two of the following criteria had to be present: (a) oligomenorrhea with inter-menstrual intervals longer than 45 days, (b) clinical (acne, hirsutism) or biochemical signs of hyperandrogenism, (c) the presence of micro-polycystic ovaries at ultrasound

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Monitoring Requirements Combining these therapies requires careful lab monitoring, including: Total and free testosterone levels Estradiol (to ensure proper aromatase balance) Complete blood count (TRT can increase hematocrit) Metabolic panel (fasting glucose, HbA1c, lipids) PSA (prostate-specific antigen) Liver and kidney function Thyroid function Labs should be checked at baseline, at 6-8 weeks after initiation, and then every 3-6 months during ongoing treatment

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