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Concurrently, patients also experienced sustained weight loss of 2.33.0 kg ( p 0.015 vs

doi: 10.1038/s41467-025-66115-x

Longer receptor occupancy may produce stronger effects but could also contribute to side effect burden

Familial hypercholesterolemia: Identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol