Key terms include: $150 million upfront payment to Yao Pharma Up to $1.935 billion in development, regulatory, and commercial milestone payments Tiered royalties on future global sales Coverage across all therapeutic, diagnostic, and prophylactic indications for both human and veterinary use This structure positions the agreement as one of the larger oral-GLP-1 licensing deals in recent years
Meet clinical BMI criteria and have no contraindications: If your BMI is 30 or higher (or 27+ with weight-related health conditions), and you don't have personal or family history of medullary thyroid cancer, Multiple Endocrine Neoplasia syndrome type 2, or other contraindications listed in the safety information, you may be a medically appropriate candidate for GLP-1 treatment
Pregnant or breastfeeding individuals There is not enough human research to evaluate fetal or infant safety
Evidence summary of lifestyle interventions in adults with metabolic dysfunction-associated steatotic liver disease
462 Targeting BCAA metabolism or using mTOR inhibitors such as rapamycin may improve heart function
Archived from the original on 31 March 2016