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A study demonstrated that GLP-1, via cAMP-systems mediated by astrocytes, inhibits the expression of IL-1beta, an inflammatory molecule that is highly implicated in cell death, brain injury, and neurodegeneration [58]

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Common patch ingredients (berberine, green tea extract, cinnamon) have modest metabolic evidence when taken orally at high doses, but zero published pharmacokinetic data shows they absorb through the skin from an adhesive patch at therapeutic levels

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