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These panels are designed to detect well-known drugs of abuse such as THC, cocaine, amphetamines, opiates, PCP, and benzodiazepines

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CHF often arises from underlying conditions like coronary artery disease, hypertension, or myocardial infarction, which weaken or stiffen the heart muscle (Francis and Tang 2003)

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Mixed effect linear regression is ideally suited to analyse using the modified intention-to-treat principle because it included multiple time points per person and all available data are modelled and extrapolated to predict missing data [35]