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These drugs bind to GLP-1 receptors in the body, activating the same beneficial effects that GLP-1 would under normal circumstances

Although you can increase your GLP-1 levels naturally, levels stay high for a longer time when you take medications designed to increase GLP-1.

Most patients are on a maintenance dose with stable side effects

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This is particularly relevant in critically ill patients, in whom generalized manipulation of nutrient-sensing and autophagy pathways may produce off-target metabolic, immunological, or hemodynamic consequences