Natural history studies in areas targeted for efficacy trials seem essential, in particular in the context of PZQ MDA
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Fatigue and low energy Fatigue on GLP-1s can happen for several reasons: reduced calorie intake, dehydration, poor protein intake, blood sugar changes, or simply feeling under-fuelled
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In terms of mechanism, M1 phenotype produces NO free radicals (NO), which causes the inhibition of secondary ALOX15 activity, while iNOS expression and NO production in M2 phenotype are inhibited (51)
JAMA Psychiatry (2020)