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The cells basically get tired of hearing the same signal and start to pull the receptors from their surface, making them less sensitive
W.MessersmithW
Specifically, L2-Cmu was engineered as a human/murine chimera (i.e., reverse chimeric antibody), such that the complementary-determining regions (CDRs) were engineered into a new framework in which the entirety of the variable regions are human and the constant regions are mouse
When glutathione is depleted, this resilience decreases
The bioavailability of glutathione is more with IV route than the oral route
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