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Some analysts said the new results showed that both drugs which Roche acquired through its nearly $3 billion acquisition of Carmot Therapeutics in December caused a higher rate of side effects than expected
Dehau, T., Cherlet, M., Croubels, S., Van Immerseel, F., & Goossens, E
[7] However, the use of GLP-1 agonists during pregnancy and lactation is less well understood, as these groups are typically excluded from clinical trials
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Still, major trials on two GLP-1 drugs (tirzepatide and semaglutide) offer some information about the impact of these medications on muscle loss, according to a 2025 analysis in Obesity Reviews