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Moreover, the limit of solubility of urate in physiologic solutions is 6.7 to 7.0 in vitro at 37 o C

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doi: 10.3390/molecules24234253 Lech MA, Leskiewicz M, Kaminska K, Rogoz Z, Lorenc-Koci E

In: Scriver CR, Sly WS, Childs B, Beaudet AL, Valle D, Kinzler KW, Vogelstein B, editors

53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis