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On the surface, it seems like a minor chemical substitution

During the first four weeks, you're experiencing dose escalationthe standard protocol begins at a low dose to minimize side effects, then increases gradually

Refrigeration slows oxidative degradation but does not stop it entirely

The colonic sections were incubated with the antibodies for 12 hours at 4 C, followed by incubation with biotinylated goat anti-rabbit IgG at 25 C for 20 min