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(5) Adverse Effects and Contraindications: The most notable adverse effect is increased blood pressure

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Swisher SG , Hofstetter W, Komaki R, Correa AM, Erasmus J, Lee JH, Liao Z, Maru D, Mehran R, Patel S, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Ajani JA

The C-terminal difference between the two variants makes GAC more specifically active, which may contribute to its greater susceptibility to overexpression in aggressive cancers (Redis et al., 2016)

The preclinical record in animals is large